Harry Kane grabbed his first goal of the season as Tottenham came from a goal down to inflict a second straight league defeat on Man City with a 4-1 win over Manuel Pellegrini’s men.
Kevin De Bruyne grabbed his third City goal in three games when Yaya Toure picked out the Belgian after a brilliant Man City counter attack on 25 minutes but Eric Dier rifled home from 25 yards to grab the equaliser just before half-time.
Toby Alderweireld headed Spurs in front just five minutes into the second half with his first goal for the club before Kane ended his goalscoring drought on the hour marked with a side-footed effort.
Erik Lamela grabbed Spurs fourth on 79 minutes when he rounded goalkeeper Willy Caballero and calmly slotted home to give Tottenham an incredible victory over Man City, who as a result drop to second in the table.
That loss allowed Man United to rise to the top of the league for the first time in two years as Louis van Gaal’s side comfortably ran out 3-0 winners over a winless Sunderland.
Memphis Depay scored his first Premier league goal to put the Red Devils 1-0 up just before the break, before Wayne Rooney grabbed his first league goal of the season less than a minute into the second half after some nice work by Anthony Martial.
Juan Mata fired into the roof of the net late on to make it 3-0 as Man United did what was needed to see them claim top spot in the Premier League to lie just one point ahead of their Manchester rivals.
Alexis Sanchez netted a hat-trick as Arsenal ended Leicester’s unbeaten run in emphatic style with a 5-2 win at the King Power Stadium as three goals from the Chilean plus goals from Theo Walcott and Oliver Giroud handed the Gunners all three points.
Under-pressure Brendan Rogers picked up a much-needed win as Daniel Sturridge was on the double in a hard-fought 3-2 win over Aston Villa, while rivals Everton fought back from two down to secure a 3-2 win at West Brom thanks to a brace from Romelu Lukaku.
Newcastle threw away a two-goal lead as Chelsea fought back from 2-0 down to secure a point at St. James Park with goals from substitute Ramires and a free-kick from Willian rescued a point for the Blues as Newcastle still search for their first win of the season.
Stoke picked up their first three points of the campaign as Mame Biram Diouf helped the Potters secure a 2-1 win over Bournemouth, while a late Cheikhou Kouyate equaliser rescued a point for West Ham in a 2-2 draw with Norwich.
Saturday 26 Sep
Tottenham 4-1 Man City (Dier 45, Alderweireld 50, Kane 61, Lamela 79 | De Bruyne 25)
Leicester 2-5 Arsenal (Vardy 13, 89 | Walcott 18, Sanchez 33, 57, 81, Giroud 90)
Liverpool 3-2 Aston Villa (Milner 2, Sturridge 59, 67 | Gestede 66, 71)
Man United 3-0 Sunderland (Memphis 45, Rooney 46, Mata 90)
Southampton 3-1 Swansea (van Dijk 11, Tadic 54, Mane 61 | Sigurdsson pen 83)
Stoke 2-1 Bournemouth (Walters 32, Diouf 83 | Gosling 76)
West Ham 2-2 Norwich (Sakho 33, Kouyate 90 | Brady 9, Redmond 83)
Newcastle 2-2 Chelsea (Perez 42, Wijnaldum 60 | Ramires 79, Willian 86)
Sunday 27 Sep
Watford 0-1 Crystal Palace (Cabaye pen 71)
Monday 28 Sep
West Brom 2-3 Everton (Berahino 41, Dawson 54 | Lukaku 55, 84, Kone 75)