Leicester moved seven points clear at the top of the table and edged closer to a first ever Premier League title after a fifth 1-0 win in their last six games was enough to secure three points against Southampton.
The only goal of the game came seven minutes before the break as Wes Morgan headed home from Christian Fuchs cross to score his first goal of the season.
Tottenham’s hopes of a first top-flight title in 55 years hit a blow after Mauricio Pochettino’s side could only manage a point at Liverpool coming from behind to earn a 1-1 draw.
Philippe Coutinho got on the end of a Daniel Sturridge pass and calmly finished a low-shot home to give the Reds a 51st minute lead but Harry Kane rescued a point for Spurs just after the hour mark with a brilliant turn and blasted home.
Arsenal kept faint hopes of a first Premier League title in 12 years alive as the Gunners smashed four past Watford in revenge for their FA Cup exit last month.
Alexis Sanchez got Arsenal off to a flyer on four minutes as the Chilean calmly pounced home after seeing his initial header saved and Alex Iwobi went from provider to goalscorer when he made it 2-0 on 38 minutes smashing in a first-time finish from Sanchez’s pass.
Hector Bellerin’s shot deflected in off Ben Watson for Arsenal’s third three minutes into the second-half, before Theo Walcott bagged a Gunners’ fourth in injury time as he slotted home from Joel Campbell’s cross.
It was also a comfortable day at the office for Man City who kept hold of fourth place, as they responded from a derby defeat last time out with a 4-0 thrashing of Bournemouth.
It took just seven minutes for the visitors to take the lead when Fernando volleyed home from Jesus Navas’ corner and it was 2-0 five minutes later, when Kevin De Bruyne placed the ball into the back off the net from David Silva’s flick.
Sergio Aguero headed home Navas’ cross to make it 3-0 inside the first 20 minutes and Aleksandar Kolarov added a fourth late on as the left-back rifled the ball home in off the far post.
Man United moved up to fifth and remain just one point off Man City in the race for that last Champions League place as Anthony Martial scored the only goal in a 1-0 win over Everton.
Down the other end of the table, Norwich boosted their hopes of survival and threw Newcastle further into trouble after Marcus Olsson scored a late winner to give Alex Neil’s side a 3-2 win over the Magpies.
Managerless Aston Villa are on the verge of relegation after Chelsea thrashed a woeful Villa side 4-0 and another loss for the Villains next weekend could see their drop to the Championship confirmed.
Saturday 2 Apr
Aston Villa 0-4 Chelsea (Hutton s/o 85 | Loftus-Cheek 26, Pato pen 45, Pedro 46, 59)
Arsenal 4-0 Watford (Sanchez 4, Iwobi 38, Bellerin 48, Walcott 90)
Bournemouth 0-4 Man City (Fernando 7, De Bruyne 12, Aguero 19, Kolarov 90)
Norwich 3-2 Newcastle (Klose 45, Mbokani 74, Olsson 90 | Mitrovic 71, pen 86)
Stoke 2-2 Swansea (Afellay 13, Bojan 53 | Sigurdsson 68, Paloschi 79)
Sunderland 0-0 West Brom (1500)
West Ham 2-2 Crystal Palace (Lanzini 18, Payet 41, Kouyate s/o 67 | Delaney 15, Gayle 75)
Liverpool 1-1 Tottenham (Coutinho 51, Kane 63)
Sunday 3 Apr
Leicester 1-0 Southampton (Morgan 38)
Man United 1-0 Everton (Martial 54)